Toxicology 21: Scientific Applications Training

Module 1

This model will give you a broad introduction to the Toxicology 21st century (Tox21c) field and familiarize you with the main document, which summarize the main ideas and principles of Tox21c

Module 2

This module will discuss how ToxCast and Tox21 technologies can be used in practice The US EPA Endocrine Disruptor Screening Program will be discussed in detail and we will demonstrate how the ToxCast platform replaced in vivo tiered approaches in EDSP and, thus, acelerate the process of In the second lesson of this module, the development of in silico models for toxicity testing will be discussed

Module 3

This module will familiarize you with the Human Toxome Project run by Johns Hopkins University in collaboration with several university, industry, and research agencies Omics technologies, their advantages and disadvantages, as well as concepts of Adverse Outcome Pathways (AOP) and Pathways of Toxicity (PoT) will be discussed

Module 4

The first lesson in this module will explain the concept of read-across, why it is important for regulatory risk assessment, and how it can be implemented by industry in response to REACH legislation The organotypic cultures lesson will teach you about existing in vitro cell-based models starting from simple monolayer cultures of cell lines and ending with complex combined organ-on-a-chip and human-on-a-chip approaches

Module 5

This module will teach you the role of miRNA and epigenetics in toxicology and environmental health

Module 6

In this module you will learn about important component of in vitro toxicology such as in vitro to in vivo extrapolation (IVIVE) and physiologically based biokinetic modeling You will learn why it is important to consider biokinetics in vitro and see some example of biokinetics modeling in vitro This lesson will also give you a biometry prospective of in vitro toxicology. You will learn which methods can be used to analyze big data

Module 7

In this lesson you will learn about integrated testing strategies and how they differ from individual tests or test batteries Also a wrap-up lesson “beyond chemical” will summaries your knowledge from this course and give a out-look for further directions in the field of alternatives to animal testing